Biochemical Modulation of Fluoropyrimidines: Is There an Optimal (6 R , S )Leucovorin Dose and Schedule?

Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin.

The growth-inhibitory effect of fluoropyrimidines combined with a short-term exposure to leucovorin and the pattern of polyglutamylation of folates were compared between parental CCRF-CEM cells and a cell line with impaired ability to form polyglutamates (CCRF-CEM/P). The combination of leucovorin with 5-fluorouracil or 5-fluorodeoxyuridine increased the growth inhibition of CCRF-CEM cells comp...

Dose Schedule and Antitumor Studies of Arabinosyl Cytosine ( NSC 6387 S ) 6 7 Writing

The University of Oklahoma Medical Center, Oklahoma City, Oklahoma The University of Texas Medical Branch, Galveston, Texas ^he University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas The University of Texas Southwestern Medical School, Dallas, Texas Tulane University School of Medicine, New Orleans, Louisiana University of Arkansas Medical Center, Little Rock, Arkansas ...

Is There an Optimal Money Supply?: Discussion

Biochemical modulation in the treatment of advanced cancer: a study of combined leucovorin, fluorouracil, and iododeoxyuridine.

Multiple studies have shown that leucovorin-fluorouracil regimens are modestly superior to fluorouracil alone in the treatment of advanced colorectal cancer. Laboratory data suggest that iododeoxyuridine could further enhance the efficacy of leucovorin-fluorouracil regimens. This report describes the Phase I clinical evaluation of a leucovorin-fluorouracil-iododeoxyuridine chemotherapy regimen....

The antineoplastic and biochemical effects of some 5-fluoropyrimidines.

5-fluoropyrimidine (2-HFP) were measured on Sarcoma 180 ascites cells. A marked extension of the life-span of tumor-bearing mice was afforded by i.p. injections of 5-FU, whereas both 4-HFP and 2-HFP were only weakly active. Sarcoma 180 ascites cells converted both 4-HFP and 5-FU into mono-, di-, and trinucleotide forms of 5-FU and incorporated the 5-fluoropyrimidines into RNA exclusively as 5-F...